| Atropine Sulfate |
Mechanism of Action
Atropine sulfate is a parasympatholytic that enhances sinus node automaticity
and atrioventricular conduction. This is done by blocking the bodies' natural
vagolytic response.
Indications
Initial therapy for symptomatic bradycardia
Can restore normal AV nodal conduction and electrical activity in patients with
first-degree AV block or Mobitz type I AV block.
Treatment of bradysystolic cardiac arrest due to excessive vagal stimulation.
Less effective, but indicated in cardiac arrest, when asystole or PEA are the
result of prolonged ischemia or mechanical injury in the myocardium
Packaging
1 mg in 10 ml (pre-pack)
Drug box inventory = 3
Onset & Duration
Onset: Rapid
Duration: 2-6 hours
Doses and Administration
In the arrest scenerio, IV Push: Give 1mg every 3-5 minutes.
Endotracheal tube: 1.0-2.0 mg in 10cc normal saline
Maximum dose should be 3 doses
Precautions
May cause worsening of myocardial ischemia
Doses less than 0.5 mg can produce a paradoxical bradycardia.
Ventricular fibrillation or Ventricular Tachycardia can occur after IV
administration.
Excessive doses can cause an anticholinergic syndrome:
Delirium
Tachycardia
Coma
Flushed, hot skin
Ataxia
Blurred vision
Pediatrics
Dose: 0.02 mg/kg IVP with a minimum dose of 0.1 mg
Maximum single doses:
Child, 0.5 mg
Adolescent, 1.0 mg
May repeat once
Maximum total dose 2.0 mg
Administer prophylactic dose of 0.02 mg/kg when intubating any patient under
16 y/o
Atropine sulfate is a parasympatholytic that enhances sinus node automaticity
and atrioventricular conduction. This is done by blocking the bodies' natural
vagolytic response.
Indications
Initial therapy for symptomatic bradycardia
Can restore normal AV nodal conduction and electrical activity in patients with
first-degree AV block or Mobitz type I AV block.
Treatment of bradysystolic cardiac arrest due to excessive vagal stimulation.
Less effective, but indicated in cardiac arrest, when asystole or PEA are the
result of prolonged ischemia or mechanical injury in the myocardium
Packaging
1 mg in 10 ml (pre-pack)
Drug box inventory = 3
Onset & Duration
Onset: Rapid
Duration: 2-6 hours
Doses and Administration
In the arrest scenerio, IV Push: Give 1mg every 3-5 minutes.
Endotracheal tube: 1.0-2.0 mg in 10cc normal saline
Maximum dose should be 3 doses
Precautions
May cause worsening of myocardial ischemia
Doses less than 0.5 mg can produce a paradoxical bradycardia.
Ventricular fibrillation or Ventricular Tachycardia can occur after IV
administration.
Excessive doses can cause an anticholinergic syndrome:
Delirium
Tachycardia
Coma
Flushed, hot skin
Ataxia
Blurred vision
Pediatrics
Dose: 0.02 mg/kg IVP with a minimum dose of 0.1 mg
Maximum single doses:
Child, 0.5 mg
Adolescent, 1.0 mg
May repeat once
Maximum total dose 2.0 mg
Administer prophylactic dose of 0.02 mg/kg when intubating any patient under
16 y/o
