| Epinephrine 1:10,000 |
Mechanism of Action
Natural catecholamine with both a- and b-adrenergic agonist activity.
Can produce the following cardiovascular responses
Increased systemic vascular response
Increased systolic and diastolic BPs
Increased electrical activity in the myocardium
Increased coronary and cerebral blood flow
Increased strength of myocardial contraction
Increased myocardial oxygen requirements
Increased automaticity
Indications
Improved coronary and cerebral profusion is the primary beneficial effect of
epinephrine during cardiac arrest. May also increase automaticity and make
VF more susceptible to DC countershock.
Infusions can be used to treat profound symptomatic bradycardia.
Used IVP in the treatment of severe anaphylaxis.
Packaging
1 mg in 10 ml (pre-pack)
Drug box inventory = 8
Onset & Duration
Onset: 1-2 min
Duration: 5-10 min
Doses and Administration
IV Push: Give 1mg every 3-5 minutes, there is no maximum dose.
Endotracheal tube: 2-2.5 mg in 10cc normal saline
Precautions
May cause worsening of myocardial ischemia
May cause PVC's or Ventricular Tachycardia.
May result in undesired tachycardia.
Pediatrics
In arrest given IVP 0.01 mg/kg (0.1 ml/kg)
Natural catecholamine with both a- and b-adrenergic agonist activity.
Can produce the following cardiovascular responses
Increased systemic vascular response
Increased systolic and diastolic BPs
Increased electrical activity in the myocardium
Increased coronary and cerebral blood flow
Increased strength of myocardial contraction
Increased myocardial oxygen requirements
Increased automaticity
Indications
Improved coronary and cerebral profusion is the primary beneficial effect of
epinephrine during cardiac arrest. May also increase automaticity and make
VF more susceptible to DC countershock.
Infusions can be used to treat profound symptomatic bradycardia.
Used IVP in the treatment of severe anaphylaxis.
Packaging
1 mg in 10 ml (pre-pack)
Drug box inventory = 8
Onset & Duration
Onset: 1-2 min
Duration: 5-10 min
Doses and Administration
IV Push: Give 1mg every 3-5 minutes, there is no maximum dose.
Endotracheal tube: 2-2.5 mg in 10cc normal saline
Precautions
May cause worsening of myocardial ischemia
May cause PVC's or Ventricular Tachycardia.
May result in undesired tachycardia.
Pediatrics
In arrest given IVP 0.01 mg/kg (0.1 ml/kg)
