| Ondansetron (Zofran) |
Mechanism of Action
A selective 5-HT3 receptor antagonist.
While ondansetron's mechanism of action has not been fully characterized, it is
not a dopamine-receptor antagonist.
Activation of vagal afferents may also cause a central release of serotonin
through the 5-HT3 receptors and initiate the vomiting reflex.
Indications
Nausea or active vomiting
Packaging
4 mg in 2 ml (vial)
Drug box inventory = 1
Onset & Duration
Onset: 3-5 min
Duration: < 12 hours
Doses and Administration
Give 4 mg IV bolus
If no IV, 4 mg IM
Precautions
Possible Seizures
Transient visual disturbances (usually in larger doses)
Chemotherapy patients may already be on an oral dose
Pediatrics
Not used in the GMVEMSC Protocol
A selective 5-HT3 receptor antagonist.
While ondansetron's mechanism of action has not been fully characterized, it is
not a dopamine-receptor antagonist.
Activation of vagal afferents may also cause a central release of serotonin
through the 5-HT3 receptors and initiate the vomiting reflex.
Indications
Nausea or active vomiting
Packaging
4 mg in 2 ml (vial)
Drug box inventory = 1
Onset & Duration
Onset: 3-5 min
Duration: < 12 hours
Doses and Administration
Give 4 mg IV bolus
If no IV, 4 mg IM
Precautions
Possible Seizures
Transient visual disturbances (usually in larger doses)
Chemotherapy patients may already be on an oral dose
Pediatrics
Not used in the GMVEMSC Protocol
