| Sodium Thiosulfate |
Mechanism of Action
An exogenous source of sulfur is available to the body, thereby allowing it
hasten the detoxification of cyanide using the enzyme rhodanese.
Rhodanese (thiosulfate cyanide sulfurtransferase) converts cyanide to the
relatively nontoxic thiocyanate ion. Thiocyanate is then excreted in the
urine.
Indications
Cyanide toxicity
Smoke Inhalation
Packaging
12.5 Gm in 50 ml (25% solution)
Drug box inventory = 1
Doses and Administration
12.5 Gm
Pediatrics
1.65 ml/kg very slow (over 3 min) Max. 12.5 gm
An exogenous source of sulfur is available to the body, thereby allowing it
hasten the detoxification of cyanide using the enzyme rhodanese.
Rhodanese (thiosulfate cyanide sulfurtransferase) converts cyanide to the
relatively nontoxic thiocyanate ion. Thiocyanate is then excreted in the
urine.
Indications
Cyanide toxicity
Smoke Inhalation
Packaging
12.5 Gm in 50 ml (25% solution)
Drug box inventory = 1
Doses and Administration
12.5 Gm
Pediatrics
1.65 ml/kg very slow (over 3 min) Max. 12.5 gm
